Though it is assumed that the progesterone sensor luminal cells constitute a developmentally terminal post mitotic state, the following observations raise doubts that cannot be ignored 1 Lack of sufficient evidence in the literature that functionally and molecularly defined ER PR luminal cells are direct products of ER PR luminal progenitor cells; 2 In humans, the telomere length of the terminal luminal cell fraction is longer than luminal progenitor cells in younger women and gradually declines with age 102; 3 A study looking at the synthetic nucleoside labeling cycling cells within defined mammary subsets in a mouse model has argued that luminal progenitor and luminal cells could represent 2 distinctly self sustained lineages with shared luminal features 201; 4 It appears that the post mitotic ER luminal cells which generally co express PR can be induced to grow and expand in vitro 202 what is priligy Do the suspicious areas last
Though it is assumed that the progesterone sensor luminal cells constitute a developmentally terminal post mitotic state, the following observations raise doubts that cannot be ignored 1 Lack of sufficient evidence in the literature that functionally and molecularly defined ER PR luminal cells are direct products of ER PR luminal progenitor cells; 2 In humans, the telomere length of the terminal luminal cell fraction is longer than luminal progenitor cells in younger women and gradually declines with age 102; 3 A study looking at the synthetic nucleoside labeling cycling cells within defined mammary subsets in a mouse model has argued that luminal progenitor and luminal cells could represent 2 distinctly self sustained lineages with shared luminal features 201; 4 It appears that the post mitotic ER luminal cells which generally co express PR can be induced to grow and expand in vitro 202 what is priligy Do the suspicious areas last